Phlotonics Turns Silicon Photonics into Real-Time Insight for the Bioeconomy

“We’re focused on downstream process development, starting with real-time monitoring at the Protein A capture step, where a single missed detection can cost a drug maker hundreds of thousands of dollars in yield.”
—Dr. Mickey Bryan, CEO of Phlotonics

Modern biomanufacturing relies on precise control of complex biological processes, yet many of the proteins that determine whether a batch succeeds or fails are still measured through offline laboratory testing. AIM Photonics member Phlotonics is working to close that information gap using silicon photonic biosensors that provide continuous, molecule-specific data throughout the biomanufacturing process.

A recent article from the Rochester Business Journal highlights how Phlotonics is developing automated biosensor instruments designed to give bioprocess teams real-time insight into critical proteins and other biological markers. The technology uses microscopic silicon photonic ring resonators to detect protein binding, helping manufacturers identify changes earlier and make informed adjustments while a batch is still running.

At the heart of the platform are Phlotonics’ proprietary sensor chips, fabricated using AIM Photonics’ 300 mm silicon photonics MPW platform at the NY Creates Albany NanoTech Complex and tested through its integrated test capabilities at the TAP facility in Rochester. This access to foundry-scale silicon photonics manufacturing is helping Phlotonics move its technology from validation toward commercial deployment in biopharmaceutical manufacturing, with potential applications in cell and gene therapy, drug discovery and other areas of the bioeconomy.

Read the full article (no subscription required) on the Rochester Business Journal.